The most successful club in the competition is Sevilla, with seven titles. The title has been won by 29 clubs, 14 of which have won it more than once. Spanish clubs have the highest number of victories (14 wins), followed by teams from England and Italy (9 wins each). The winner of the UEFA Europa League qualifies for the UEFA Super Cup, for the following season's UEFA Champions League since the 2014–15 season, entering at the group stage, as well as for the UEFA–CONMEBOL Club Challenge - a friendly cup against the winners of the CONMEBOL Copa Sudamericana - since 2023. The 2009 re-branding included a merge with the UEFA Intertoto Cup, producing an enlarged competition format, with an expanded group stage and a change in qualifying criteria. The competition took on its current name in 2009, following a change in format. From the 2004–05 season a group stage was added before the knockout phase. In 1999, the UEFA Cup Winners' Cup was merged with the UEFA Cup and discontinued as a separate competition. Clubs qualify for the competition based on their performance in their national leagues and cup competitions. The UEFA Cup was the third-tier competition from 1971 to 1999 before the UEFA Cup Winners' Cup was discontinued, and it is still often referred to as the 'C3' in reference to this.

Introduced in 1971 as the UEFA Cup, it replaced the Inter-Cities Fairs Cup. It is the second-tier competition of European club football, ranking below the UEFA Champions League and above the UEFA Europa Conference League. The UEFA Europa League (previously known as the UEFA Cup, abbreviated as UEL, or sometimes, UEFA EL) is an annual football club competition organised since 1971 by the Union of European Football Associations (UEFA) for eligible European football clubs.

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